ADCs increasing in clinical performance stature
The antibody-drug conjugate ifinatamab deruxtecan demonstrated “robust and durable efficacy” in patients with heavily pretreated small cell lung cancer, according […]
Read MoreAuthor: AnnaH
Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme
The results from the eye-wateringly huge whole-genome sequencing (WGS) project on 13,880 tumors are finally published in this month’s Nature […]
Read MoreCirculating Tumor Cells: Pathological, Molecular and Functional Characteristics 2.0
Guest Editor: Dr. Ewa A. Grzybowska, Cancer Center Institute, Roentgena 5, 02-781 Warsaw, Poland. Email: Ewa.Grzybowska@coi.pl Deadline for manuscript submissions: […]
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Clinical and pathological factors predicting axillary nodal metastasis in breast cancer patients of central Sudan: A single institution experience
The aim of this study is to provide baseline information of the clinical and pathological factors predicting ALN metastasis in patients who underwent modified radical mastectomy or breast conserving surgery at Wad-Madani Teaching Hospital, Sudan.
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Berberine Chloride and Hyperthermia Promote Osterix Expression and Suppress Cell Cycle Genes in Osteosarcoma Cells
The objective of this study is to investigate the effects of berberine chloride and hyperthermia on the expression of Osterix (Osx), Runt-related transcription factor 2 (RUNX-2), receptor activator of nuclear factor kappa-B ligand (RANKL), cyclin-dependent kinase 2 (CDK2), CDK4, interleukin (IL)-6 and IL-11 genes.
Read MoreThe Nuts and Bolts of an Inpatient Cardio-Oncology Consult Team
Cancer therapies can affect the whole cardiovascular system, but these cardiotoxic effects are generally reported as changes in left ventricular (LV) ejection fraction. The most common cardiovascular adverse effects are LV dysfunction and heart failure (HF). Other adverse effects include hypertension, acute coronary syndromes, thromboembolic events, rhythm disturbances, and valvular and/or pericardial disease. Hence, prediction, early recognition, and timely management of cardiovascular complications in patients with cancer are gaining importance. This need gave birth to the concept of interdisciplinary cardiology-oncology (cardio-oncology) care delivered through teams of cardiologists, oncologists, and hematologists.
Read MoreMutation Frequencies in Endometrial Cancer Patients of Different Ethnicities and Tumor Grades: An Analytical Study
Endometrial carcinoma is a predominant health problem for women worldwide. However, there is a lack of data on genetic mutation frequencies in endometrial cancer patients of different ethnicities and tumor grades. The objective of this study is to provide data regarding mutation frequencies in endometrial cancer patients of different ethnic groups and tumor grades by analyzing large-scale cancer genomic datasets of a database.
Read MoreProfessor John G Gribben explains why CART-cell therapy has the potential to revolutionise cancer treatment.
CAR T-cell (chimeric antigen receptor T-cell) therapy is a recent, exciting advancement as a form of immunotherapy, offering a new, […]
Read MoreConfining cell-killing treatments to tumours
Cytokines, small proteins released by immune cells to communicate with each other, have for some time been investigated as a […]
Read MoreBreast cancer risk-factors and benefits of early screening
Although breast cancer is the most common type of female cancer throughout the Middle East, many women do not seek medical care promptly. Consequently, the region has increased rates of late incidences. Dr Marwan Elbagouray explains breast cancer risks and the benefits of early screening.
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