The Nuts and Bolts of an Inpatient Cardio-Oncology Consult Team

By Dr Samer Ellahham MD CPHQ CMQ EFQM FACC FAHA


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Cancer therapies can affect the whole cardiovascular system, but these cardiotoxic effects are generally reported as changes in left ventricular (LV) ejection fraction. The most common cardiovascular adverse effects are LV dysfunction and heart failure (HF). Other adverse effects include hypertension, acute coronary syndromes, thromboembolic events, rhythm disturbances, and valvular and/or pericardial disease. Hence, prediction, early recognition, and timely management of cardiovascular complications in patients with cancer are gaining importance. This need gave birth to the concept of interdisciplinary cardiology-oncology (cardio-oncology) care delivered through teams of cardiologists, oncologists, and hematologists.

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Metabolic reprogramming of branched-chain amino acid facilitates drug resistance in lung cancer

By Richard Hindle


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Researchers have revealed the important role of epigenetic regulation-mediated metabolic reprogramming in lung cancer’s capacity to resist molecular targeted therapy.

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Combination treatment, diabetes drug and immunotherapy, may help to fight breast cancer

By Richard Hindle


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MYC, a gene with high cancer-initiating potential, is overexpressed in over 40% of breast cancers.
While MYC programs breast cancer cells to build more macromolecules (anabolic metabolism), it also creates a metabolic vulnerability by making them more sensitive to a type of cell death known as apoptosis. Research Director Juha Klefstrom, PhD, University of Helsinki, Finland, has worked for a long time to exploit this apoptosis-sensitising effect of MYC in the battle against the cancer.

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New study identifies specific obesity-related risk factors for kidney cancer

By Richard Hindle


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A new study confirms the long-suspected role of obesity as a risk factor for developing renal cell carcinoma (RCC), a type of kidney cancer, and identifies several specific obesity-related factors.

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