Clinical and pathological factors predicting axillary nodal metastasis in breast cancer patients of central Sudan: A single institution experience

By Dr Mohamed Daffalla Awadalla Gismalla


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The aim of this study is to provide baseline information of the clinical and pathological factors predicting ALN metastasis in patients who underwent modified radical mastectomy or breast conserving surgery at Wad-Madani Teaching Hospital, Sudan.

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Mutation Frequencies in Endometrial Cancer Patients of Different Ethnicities and Tumor Grades: An Analytical Study

By Dr Mohammad Althubiti


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Endometrial carcinoma is a predominant health problem for women worldwide. However, there is a lack of data on genetic mutation frequencies in endometrial cancer patients of different ethnicities and tumor grades. The objective of this study is to provide data regarding mutation frequencies in endometrial cancer patients of different ethnic groups and tumor grades by analyzing large-scale cancer genomic datasets of a database.

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Ovarian cancer cells stop moving when deprived of the protein Ran

By Richard Hindle


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Researchers have shown the key role that a protein called Ran plays in the mobility of ovarian cancer cells. They demonstrated these cells cannot migrate from cancerous sites without the help of Ran.

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Blood test may predict risk of recurrence for breast cancer patients

By Richard Hindle


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A special blood test may one day predict if a newly diagnosed breast cancer patient will likely relapse years later, a City of Hope study suggests.

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Circulating tumour DNA gives treatment options for the most common ovarian cancer type

By Richard Hindle


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High-grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of ovarian cancer. The HGSOC tumours consist of several heterogeneous cell populations with a large number of mutations. This genetic variability makes it difficult to find drugs that would kill all the cancer cells, and to which the cells would not become resistant during treatment. Over half of the patients diagnosed with high-grade serous ovarian cancer die within five years of diagnosis, that is, annually more than 150 000 women globally.

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DNA test is an effective cervical cancer screening tool for women in low-income countries

By Richard Hindle


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Cervical cancer is a major issue in low- and middle-income countries due to the lack of adequate screening such as routine Pap smear testing. These countries have high incidences of cervical cancer linked to human papillomavirus (HPV). Due to lack of resources for cancer screenings, these countries account for 85 percent of all cervical cancer cases.

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Diet high in leucine may fuel breast cancer’s drug resistance

By Richard Hindle


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A team of researchers has discovered an unexpected relationship between levels of the amino acid leucine and the development of tamoxifen resistance in ER breast cancer.

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Cervical cancer is more aggressive when human papillomavirus is not detected

By Richard Hindle


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Cervical cancer negative for the human papilloma virus (HPV) is rare but more aggressive: it is more frequently diagnosed at advanced stages, with more metastasis and reduced survival. These conclusions are published in Modern Pathology. The study was co-led by ISGlobal, an institution supported by “la Caixa”, the Hospital Clinic and the University of Barcelona.

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